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Scientific studies conducted by Drs. Arora,...
Dr. Gaurav Arora, assistant professor of biology,co-authored an article which was published in the journal,Helicobacter.
Appearing in the online version of Helicobacteron November 27, 2015, Arora’s article will be includedin the journal’s next print publication. The article isco-authored by Alexandra Kyrillos, Bradley Murray, andDr. Anne G. Rosenwald, and is titled“The Presence of Phage Orthologous Genes in Helicobacter pyloriCorrelates with the Presence of the Virulence Factors CagA and VacA.”
Helicobacter pylori (or H.pylori)is a bacterium that is found in nearly everyone’s stomach;certain strains are known to cause stomach ulcers andgastric cancer. Arora’s research focuses on the genes ofthese harmful strains of bacteria. Typically, genes arepassed down from one generation to the next in a processknown as vertical gene transfer, but it is also possiblefor genes to be passed from one organism to another in what is called horizontal gene transfer.
Focusing on this horizontal gene transfer, Arora and hiscolleagues studied 335 strains of H.pyloriand identified 125, which may have acquired genes in this manner.These genes were transferred from viruses which infect bacteriaknown as phages. The research showed a correlation between theH pylori strains which exhibit horizontally transferredgenes and the strains, which can cause disease.
The published findings represent the sixth time Arora’s work hasappeared in a scientific journal. Arora received his Ph.D.in biology from Georgia Institute of Technology, where his doctoralthesis focused on understanding the evolutionary differences betweenhuman and chimpanzee apoptotic function. He conducted his post-doctoralfellowship at Georgetown University in the lab of Dr. Anne Rosenwald,his mentor and a co-author of the Helicobacter article.
The study was funded by a National Science Foundation grant,titled the Genome Solver, of which Rosenwald and Arora are co-principal investigators.“The goal of [the Genome Solver] is to recruit undergraduateresearchers at universities and give them first hand researchexperience before they graduate,” explained Arora. He views this asbeneficial for both the students and their advisors and pointedout that two of the authors of the H.pylori paper wereactually undergraduate researchers at Georgetown University.“I am hoping I can replicate this model at Gallaudet Universityand give undergraduate students research experience so that theycan use it once they graduate,” Arora said.
At Gallaudet, Arora teaches Introduction to Biologyand hopes to recruit undergraduate students to analyzedata in the field of bioinformatics. This branch ofbiology uses computer tools to analyze genomes (complete DNA/RNAsets of various organisms), and all of the work done on theH.pylori project was complete using bioinformatics tools.The advent of technology has resulted in a vast amount of datawhich exceeds the number of qualified experts to analyze it.“Bioinformatics has fast become an interdisciplinary fieldand has attracted many students from different universities,” said Arora.“As more DNA or genomic data becomes available,the need for bioinformatics experts will increase.”
Dr. Adebowale E. Ogunjirin’s research highlightedin Neurochemical Research article
Dr. Adebowale E. Ogunjirin, assistant professor of biology,co-authored an article which appeared in the October 2015issue of Neurochemical Research. The article, entitled“Competition, Selectivity and Efficacy of Analogs of A-84543 forNicotinic Acetylcholine Receptors with Repositioning of Pyridine Nitrogen,”represents Ogunjirin’s second published work,which shows possibilities that may lead to developingmedications to improve treatment for various neurological disorders.
In explaining his research, Ogunjirin offered an analogy of amaster key which can open several locks. In the same way,neurotransmitters in the body can activate multiple receptor sites.Yet, unlike a master key where specific locks are chosen,neurotransmitters indiscriminately target their sites.When the quantity of neurotransmitters is off balance due todiseases such as Alzheimer’s or Parkinson’s, drugs may beintroduced in an attempt to restore the balance. Creating adrug that will behave like a neurotransmitter (master key)but only at specific sites (chosen locks) is in essence the quest of Ogunjirin.“My research objectives focus on synthesizing and testingsmall organic molecules that will behave like a naturalneurotransmitter but binding and activating onlya specific part of the body where it is needed,” said Ogunjirin.“This way, the drug is more effective in treating the disease with minimum side effects.”
In 1999, Ogunjirin earned his M.Sc. in pharmaceutics in Nigeriaand was employed by the Pharmacists’ Council of Nigeria as aninspector of drug manufacturing companies until 2005.The following year, he began teaching biology at Gallaudetand received his Ph.D. in pharmacology from nearby Howard University in 2011.
Today, Ogunjirin teaches introductory biology atGallaudet and hopes to continue his work on campuswith student assistance. “My research will furtherbenefit our students at Gallaudet University who areinterested in gaining ample experience in the healthfield and provide additional diversity of discipline for our students,” he said.
Ogunjirin pointed out that if novel compounds are discovered,scientific knowledge would be advanced. This could potentiallyhave an immediate impact on Gallaudet in both increased recognition and funding.
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